Open Questions: AIDS
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See also: The immune system
Introduction
Site indexes
-
Epidemics and AIDS Links
- A selective list of some of the larger and more comprehensive
pages on the subject, by
Paul Bugl.
-
Galaxy: AIDS and HIV
- Categorized site directory. Entries usually include
descriptive annotations.
Sites with general resources
-
New Scientist Special Report on HIV and AIDS
- Primarily offers links to many news articles from the past
several years of New Scientist magazine. But there are
also other features, including facts and figures, external links,
frequently-asked questions, and a short bibliography.
-
Center for HIV Information
- Umbrella site for HIV/AIDS information, provided by the
University of California at San Francisco. Resources include
HIV Insite and
information on experimental
AIDS vaccines.
-
HIV Insite
- A gateway to HIV and AIDS information. Includes a knowledge
base of HIV/AIDS information, news, external links.
Provided by the
Center for HIV Information.
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AIDSinfo
- Information provided by the U. S. Department of Health and
Human Services about drugs, vaccines, clinical trials, and
miscellaneous topics. Includes an extensive
glossary and
fact sheets.
-
Division of Acquired Immunodeficiency Syndrome
- Provides information and resources related to many
aspects of AIDS & HIV. Part of the
U. S. National Institute of Allergy and Infectious Diseases.
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HIV Vaccines
- "This web site provides a comprehensive overview of AIDS
vaccine discovery and development." The site is maintained by the
Division of Acquired Immunodeficiency Syndrome. It
includes a good tutorial on
AIDS vaccine concepts and design.
There is a related series of pages from the same organization on
HIV Vaccines.
-
Johns Hopkins AIDS Service
- Provides general information about AIDS and HIV. There is a
nice description of the
HIV life cycle, including a flash animation. Also includes
questions and answers and a
literature review.
-
International AIDS Vaccine Initiative
- "IAVI is a global not-for-profit organization working to
speed the search for a vaccine to prevent HIV/AIDS, focusing
on developing countries." The site includes information on the
science of potential AIDS vaccines.
Surveys, overviews, tutorials
-
AIDS
- Article from
Wikipedia.
See also
Antiretroviral drug.
-
HIV and AIDS Tutorial
- Excellent set of pages providing a tutorial on HIV and AIDS.
Part of
The Biology Project's section on
Immunology.
-
AIDS
- General overview of AIDS epidemiology, pathogenesis,
treatment, and prevention, provided by the U. S.
National Institute of Allergy and Infectious Diseases.
-
The HIV-AIDS Connection
- Short single-page summary of evidence for the connection
between HIV and aids, provided by the U. S.
National Institute of Allergy and Infectious Diseases.
The page refers to a collection of
additional documents and resources related to this issue.
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Basic Information About AIDS and HIV
- Nice collection of brief tutorials on important aspects of
AIDS and HIV.
-
Ten Years Later, AIDS Vaccine Search Continues
- May 2007 Scientific American If Focus article, subtitled
"Science gets closer, but a fully effective vaccine remains elusive."
-
HIV Plays Both Offense and Defense
- April 2001 Scientific American news article about
how HIV destroys immune system cells.
-
HIV's Gender Bias
- March 2001 Scientific American news article about
gender differences in the way HIV infection progresses.
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A New AIDS Vaccine Candidate
- March 2001 Scientific American news article about
an experimental vaccine that prevents the development of AIDS
in monkeys.
-
Why Haven't We Found an AIDS Vaccine?
- February 2001 Scientific American article that offers
opinions about the answers to the question.
-
New Protein Blocks HIV
- January 2001 Scientific American news article about
a protein that can inhibit HIV infection by blocking the virus's
entry into cells.
-
Genetic Risk Factor for HIV Also Confers Benefit
- November 2000 Scientific American news article about
a variant of an immune system gene that both makes a person
more susceptible to HIV infection and slows the progression of AIDS.
-
B Cells May Help Maintain HIV Infection
- August 29, 2000 news release on the role of immune system B
cells in HIV infection.
-
HIV hitches a ride to get inside
- March 2000 news article about how HIV uses dendritic cells to
enter the body.
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Cracking Open AIDS's Shell
- July 1996 Scientific American In Depth article about
the strucure of the HIV capsid protein.
- What Activates AIDS?
Damaris Christensen
Science Week, June 8, 2002, pp. 360-361
- In spite of two decades of research, it is still not understood
how the virus overcomes a person's immune system and why this
happens in come cases but not others. But the search may
be narrowing to the process called immune activation.
[References]
- Merck's Mission: An AIDS Vaccine
Jon Cohen
Technology Review, March 2002, pp. 56-67
- At the time in 1984 that HIV was identified as the probable
cause of AIDS, it was hoped a vaccine might be ready for testing
within two years. The problem proved much harder than expected.
There are now a handful of vaccines in early clinical trials,
and at least one major company -- Merck -- has committed a
very substantial amount of resources to the effort.
-
Improving HIV Therapy
John G. Bartlett; Richard D. Moore
Scientific American, July 1998, pp. 84-93
- AIDS has proven frustratingly difficult to develop therapies
for, due to the rapid mutability of the HIV. But progess is being
made using drugs that counteract the effects of HIV in a variety
of ways.
- HIV Vaccines: Prospects and Challenges
David Baltimore; Carole Heilman
Scientific American, July 1998, pp. 98-103
- One of the reasons HIV is so difficult to deal with is that
the body's natural immune responses do not destroy it. A successful
vaccine for HIV will need to do more than generating antibodies.
-
In Search of AIDS-Resistance Genes
Stephen J. O'Brien; Michael Dean
Scientific American, September 1997, pp. 44-51
- Genetic factors that confer some protection against AIDS are
being discovered. The mechanisms of such protection may suggest
approaches to treatment of the disease.
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Copyright © 2002 by Charles Daney, All Rights Reserved